K podocytopathies, characterized histologically by diffuse foot process effacement in the absence of glomerular capillary wall immune complex deposition or endo. The genetic basis of human glomerular disease advances. We would like to show you a description here but the site wont allow us. Pancytopenia is a problem which confronts orthopaedic surgeons from time to time, and. Pseudocrescents may be the result of exuberant proliferation of dedifferentiated podocytes or of renopoietic. Podocytopathies are diseases where the cell that is primarily injureddysfunctional is the podocyte.
Download as ppt, pdf, txt or read online from scribd. Most podocytopathies can recur after transplantation. Powerpoint is the worlds most popular presentation software which can let you create professional pathophysiology of hypertension powerpoint presentation easily and in no time. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Platelets are small,regularly shaped clear cell fragments ranging from 2 3 micro meter in diameter i. Winner of the standing ovation award for best powerpoint templates from presentations magazine. The evolution of the classification of nephrotic syndrome. I know that while making the choice to recover was crucial, and having the will comes in handy, but it is the girls in this program and their support that has helped me make it. Doseresponse for 25ohd and function 0 20 40 60 80 100 120 140 160 180 200 220 240 3. Proteinuria and nephrotic syndrome in the 21st century the attention of scientists, nephrologists and pathologists has been recently focused on the role of podocytes as cause of proteinuria in the last 10 years lot of progress has been made in the understanding the biology of podocytes, how they function. Chapter 52 assessment of the musculoskeletal system bone cancer. Indian journal of nephrology vol 26, supplement 1 2016 indian journal of nephrology v olume 2 6 supplement 1 2016 pages s1 s highlights of the issue n understanding podocytopathies n hpa axis in patients on modified ponticelli therapy n arterial stiffness as cvd risk marker in ckd indian society of nephrology guidelines for. For 25ohd levels of 81 nmoll or higher compared to 43. For this reason, once chronic kidney disease progresses beyond a specific threshold it has been considered to be irreversible.
However, remission of the disease and regression of renal lesions have been observed in experimental animals and even. Chandan n intern, department of medicine, mims, mandya 2. Kopp 2009 advances in the biology and genetics of the podocytopathies. However, these disorders substantially decrease their quality of life and have a large effect on healthcare systems.
Pathogenesis of nephrotic syndrome free download as powerpoint presentation. The podocyte is a terminally differentiated cell of the renal glomerulus that, by wrapping around the basement membrane through its foot processes, controls the selective permeability of the glomerular filtration barrier. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Although most of the inherited glomerular diseases have in common. Ppt monoclonal antibodies for podocytopathies powerpoint. Pdf pathology of podocytopathies causing nephrotic syndrome. Department of internal medicine 2, clinical immunology and allergology. It is the study of the biologic and physical manifestations of disease as they correlate with the underlying abnormalities and physiologic disturbances. On the basis of pathophysiology, light microscopic and ultrastructural evaluation, the podocytopathies include minimal change disease, diffuse mesangial sclerosis, focal segmental glomerulosclerosis and collapsing glomerulopathy. In recent years, the identification of diseasecausing mutations and genetic variants in complement regulatory proteins has contributed significantly to our knowledge of the pathogenesis of complement associated glomerulopathies. Communitybased care home care management health teaching health care resources disorders of the hand dupuytrens contractureslowly progressive contracture of the palmar fascia resulting in. Proteinuria and nephrotic syndrome the present neptune international effort with the following major goals. Pdf pathology of podocytopathies causing nephrotic. Pathogenesis of nephrotic syndrome genetics dominance.
Pdf converter is a online webbased document to pdf converter software. Recent insights have defined the central role of the podocyte as both the regulator of glomerular development as well as the determinant of progression to. These injuries can have genetic causes, or can be caused by viral infection. In the publish as pdf or xps dialog box, choose a location to save the file to. Alright, now in this part of the article, you will be able to access the free pdf download of diagnostic atlas of renal pathology 2nd edition pdf using our direct links mentioned at the end of this article. Genetic risk is more commonly described among children with steroidresistant. Pathology of podocytopathies causing nephrotic syndrome. Clinical and molecular research aimed to understand glomerular disease has emerged to one of the most active areas in renal research at large. Scribd is the worlds largest social reading and publishing site. Pathophysiology does not deal directly with the treatment of disease. It is apparent that classification of the podocytopathies. Sometimes an immature blast cell have two gene mutations which prevent it from maturing into a specialized blood cell and cause it to multiply out of control.
Definition myopathies are disorders with structural changes or functional impairment of muscle. The term is most literally applied to a group of genetically mediated conditions where a mutation in a podocytespecific gene leads to a clinical phenotype including proteinuria. Monoclonal antibodies for podocytopathies 50 the podocytopathies, including minimalchange nephropathy, focal segmental glomerulosclerosis, c ollapsing glomerulopathy, and diffuse mesangial sclerosis, involve diverse types of injury to podocytes. Laryngeal carcinoma transglottic cancers cross the ventricle vertically involve both true vocal cord and ventricular band associated with a fixed vocal cord very invasive supraglottic cancers epiglottis, ventricular band, aryepiglottic fold, arytenoid body. Both intrinsic cell damage and reactive mechanism of injury may play a role in podocyte injury, provided a predisposing genetic background. Advances in the biology and genetics of the podocytopathies implications for diagnosis and therapy. Thrombopoiesis presented by 4112012 faisal ashfaq what are platelets. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Podocytopathies are the most common group of glomerular disorder leading to proteinuria. Doing so will enable you to better participate in class discussion and formulate questions before class. The unraveling of genetic causes resulting in proteinuria has helped to define roles for each component of the glomerular filtration barrier in the development of urinary protein loss. Chondrosarcoma microscopic these tumors are composed of lobules of. Pathology of podocytopathies causing nephrotic syndrome in. Renal progenitors in nondiabetic and diabetic nephropathies.
Save powerpoint presentations as pdf files office support. Newly formed bone forms the inner portion of the head and stalk chondrosarcoma chondrosarcomas comprise a variety of tumors sharing the ability to produce neoplastic cartilage chondrosarcoma gross features site. The gout eraser is a short, to the point guide on how to reverse gout symptoms without ever leaving your home. However, in rare instances, systemic lupus erythematosus patients with nephrotic syndrome have kidney biopsy findings of normal glomeruli or focal segmental. A unifying view of glomerular diseases rc wiggins1 1nephrology division, department of internal medicine, university of michigan, ann arbor, michigan, usa glomerular diseases encompass a broad array of clinicopathologically defined syndromes which together. Idiopathic nephrotic syndrome in children sciencedirect. Understanding podocytopathy and its relevance to clinical. The cause remains unknown but the pathogenesis of idiopathic ns is thought to involve immune dysregulation, systemic circulating factors, or inherited structural abnormalities of the podocyte. Cardiovascular pathology is the property of its rightful owner. Surgical management preoperative care operative procedure postoperative care bone cancer. This helps you give your presentation on pathophysiology of hypertension in a conference, a school lecture, a business proposal, in a webinar and business and professional representations. Idiopathic nephrotic syndrome in children the lancet. Diagnostic atlas of renal pathology 2nd edition pdf free. Click create pdf xps document, then click create pdf xps.
Kidney diseases caused by complement dysregulation. It is apparent that classification of the podocytopathies on the basis of morphology alone is. However, in rare instances, systemic lupus erythematosus patients with nephrotic syndrome have kidney biopsy findings of normal. When you save presentation as a pdf file it freezes the formatting and layout. This leads to a decrease in platelets, red blood cells rbcs and white blood cells wbcs.
Recent insights have defined the central role of the podocyte as both the regulator of glomerular development as well as the determinant of progression to glomerulosclerosis. Type ii diabetes in the nhanes iii, including 6228 adults age 20 years and older, there was a dosedependent inverse association between serum 25ohd concentration and risk of diabetes. These immature blast cells crowd the bone marrow and impair the ability of the bones to make healthy blood cells. Communitybased care home care management health teaching health care resources disorders of the hand dupuytrens contractureslowly progressive contracture of the palmar fascia resulting in flexion of the fourth or fifth digit of the hand. Monoclonal antibodies for podocytopathies is the property of its rightful owner.
Features of diagnostic atlas of renal pathology 2nd edition pdf heres a quick overview of the important features of this book. Ppt cardiovascular pathology powerpoint presentation. See more than 700 high quality representative images of light, immunofluorescence, and electron microscopy for each diagnostic entity with correlations to clinical presentation and pathogenesis. Ppt cardiovascular pathology powerpoint presentation free. The guide goes into extensive detail on exactly what you need to do to safely, effectively and permanently get rid of gout, and you are guaranteed to see dramatic improvements in days if not hours. Professor of medicine, kharkov state medical university. Although most of the inherited glomerular diseases have. If so, share your ppt presentation slides online with. Pancytopenia is a problem which confronts orthopaedic surgeons from time to. Appel md fasn wai lang lau, md, is instructor of medicine and glomerular fellow, and gerald appel md, fasn, is professor of medicine at the glomerular center of columbia university college of physicians and surgeons. People can view the slides even if they dont have powerpoint, but they cant make changes to it. Leukemia pathophysiology video leukemia khan academy. Diagnostic atlas of renal pathology 2nd edition pdf free download.
Inherited and acquired dysregulation of the complement alternative pathway plays an important role in multiple renal diseases. At least 10% of adults and nearly all children who receive renalreplacement therapy have an inherited kidney disease. Pathophysiology is which address the etiology, development, and elimination of pathological processes. It does not include upper motor neuron lesions, lower motor neuron lesions, myasthenia gravis which also causes muscle weakness. The genetic basis of human glomerular disease advances in. However, these disorders substantially decrease their quality of life and have a large effect on healthcare. The incidence of idiopathic nephrotic syndrome ns is 115169 per 100 000 children, varying by ethnicity and region. The understanding of these podocytopathies has greatly expanded in recent years, particularly with the discovery of more than a dozen genetic mutations that are associated with loss of podocyte functional integrity. Final diagnosis of the podocytopathies should occur in 3 steps. Pathophysiology of hypertension powerpoint presentation. Genetic risk is more commonly described among children with. In systemic lupus erythematosus, nephroticrange proteinuria typically signals the presence of a proliferative lupus nephritis class iiiiv andor membranous lupus nephritis class v, with or without concomitant class iii or iv lesions.
Advances in the biology and genetics of the podocytopathies. Convert and create pdf from various types of files like word doc, excel xls, powerpoint ppt. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Rhinitis infectious rhinitis common cold viral adenoviruses, echoviruses, rhinoviruses allergic rhinitis hay fever plant pollen, dust mites, animal allergens.
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